Month: October 2011

The Cochrane Collaboration urges use of clinical information to make better decisions, clinical and health.

The Cochrane Collaboration calls to use clinical information to make better clinical decisions and health.

Colloquium Cochrane nineteenth – “ scientific evidence for health care quality and patient safety ”.

-the excess of scientific information generated throughout the world impedes doctors process this information and that explains, in part, that one of every four patients will not receive the best possible health care

-The Cochrane Collaboration is the best institution of evidence-based medicine to help make decision-making more effective, efficient and safe for the patient

– “ all treatments that have proven to be effective, must be free ”, so says Dr. Xavier Bonfill, director of the Iberoamerican Cochrane Centre and Chairman of the Executive Committee of the nineteenth Colloquium Cochrane

Madrid, 2011-October “ doctors carry out interventions that or do not work or even cause damage and, therefore, should not take place. Thus, 25% of patients do not receive effective treatments and that same percentage of patients do not receive treatments that have been effective ”, says Dr. Jonathan Craig, co-Chair of the Cochrane Collaboration in the framework of the nineteenth Colloquium Cochrane held in Madrid.

why is this happening? Because in part, says doctor Craig, by the excessive volume of clinical information. “ There are between 700,000 and one million of clinical trials in the world and it is not possible that a medium clinical process this information. our goal is to find all the trials of a medical practice, evaluate them, summarize them and spread them all over the world to make it accessible to clinicians, political and patients ”.

Dr. Xavier Bonfill, director of the Iberoamerican Cochrane Centre ensures, for its part, following the ideology of the mentor of this organization, the British doctor Archie Cochrane, “ all treatments that have proven to be effective, must be free ”. “ Apparently not learned from history nor good ideas made many years ago –-continuous doctor Bonfill — because we are now at a time in which we continue discussing if we claim that all treatments must be free or only those that have proven effective … we would like to ensure that the second option is better but we have not developed neither a culture, or the mechanisms to make this discrimination between those who are effective for those who are not … and in the work of explanation, we are ”.

Dr. Jeremy Grimshaw, co-Chair of the Cochrane Collaboration, considers that assess quality in health care initiatives must be “ first to determine whether the activities carried out are beneficial or harmful, and second, because sometimes you have to repeat studies which invests money thinking that serve to improve the quality of care and are then failed and not show an effective ”.

Gordon Guyatt, Professor of clinical epidemiology and Biostatistics of McMaster University in Hamilton, Ontario and father of evidence-based medicine has pointed out that “ it is important that although we have little evidence on a particular type of clinical performance, these tests are of quality not to waste resources ”. Hence the importance of systematize an appropriate methodology for assessing the degree of confidence and quality of health actions. In this task, continues Dr. Guyatt, “ have developed the method GRADE, an initiative that has revolutionized the world of guidelines for clinical practice and, in general, of the formulation of recommendations on health ”.

Mirta Roses, Director General of the Pan American Health Organization (PAHO) stated outright so “ there is no health without research and is important that in situations of economic crisis, as the current crisis is an opportunity for improvement and not a repetition of past mistakes ”.

“ In the same way – says Mirta Roses – in the area of the Americas there is a huge gap between some countries and others depending on the degree of development and improving people’s health is our priority ”.

We must regain the credibility of the population to health care through the scientific evidence and that is why, says the Director General of PAHO, “ is essential translation and transmission of scientific knowledge and make it reach the population, the researcherspoliticians and the media. The ethical and regulatory framework is also fundamental and that is where the Cochrane Collaboration has put emphasis in helping the formation of professional volunteers ”

in the plenary session devoted to patients and citizens the challenges of the security and quality health care, the new model of patient active has become apparent in the field of health; the need to include the participationdoes the patient in the decision-making of health systems and the importance of the network of training citizens to advance in the improvement of the quality of care.

Involving patients in the prioritization of health research is one of the fundamental objectives of the Cochrane Collaboration. In United Kingdom there is a very suggestive initiatives such as the one made in collaboration with the James Lind Alliance. According to his Manager, Sally Crowe, “ have the need for patients to be involved in the review of the health research because they contribute with their taxes to fund this research. In United Kingdom there are large imbalances between what is researched and that patients require you to look into. It is important to bring together in a same group of researchers, clinicians, and patients to know better to influence decisions affecting people’s health ”.

Silvana Simi, representative of the Cochrane Group of patients with multiple sclerosis in Italy says that “ patients should not be silent. They are not exploited source to analyze how health services and its voice must take into account because it, everyone wins ”.

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20% Of the patients anticoagulados are poorly controlled.

20% Of the patients anticoagulados are poorly controlled.

– 600,000 people who are dealing with oral anticoagulants in Spain, 75 per cent do so as a result of cardiovascular disease, mainly for the treatment of atrial fibrillation atrial.

-The most commonly used anticoagulants are in Spain acenocoumarol and warfarin in the rest of the world. These blood thinners do not guarantee its effectiveness in all patients that 20% of people taking them suffer a high risk of embolism or hemorrhage

– over the past years is being carried out numerous studies that are focused on achieving a more effective than the acenocoumarol or warfarin anticoagulant. The dabigatran is best known, but new studies that are demonstrating the effectiveness of the apixaban and the rivaroxaban

– a study to more than 18,000 patients, RE-LY, demonstrated that the dabigatran dose of 150 mg and compared with warfarin decreases the risk of strokesystemic embolism, hemorrhagic stroke, vascular mortality and total bleeding

-the study ARISTOTLE, for its part, showed that apixaban compared with warfarin decreases the risk of stroke by 31% by 21% the risk of bleeding and death by 11%. With regard to rivaroxaban, the Rocket study has shown that it can compete with warfarin in preventing stroke, without significantly increasing the number of severe bleeding

-representatives of the Spanish society of Cardiology (SEC) have submitted these developments on the occasion of the Congress of the cardiovascular diseases SEC 2011 began ael last Friday and lasted until Saturday 22 in Maspalomas

Maspalomas, October of 2011- the Spanish society of Cardiology ( SEC ) announced, in the framework of the celebration of the Congress of the SEC 2011 cardiovascular diseases, new advances in anticoagulant drugs, currently, 20% of patients taking these medications are poorly controlledi.e., have a high risk of embolism or hemorrhage.

The main function of anticoagulant treatment is to make blood more liquid, used to prevent clot formation and thus avoid the risk of stroke. Despite the effectiveness in 80% of cases of current anticoagulant drugs, they presented serious problems of variability, that there is a fixed dose of the drug, but it should conform to each person on the basis of an analytical must practice regularly (every four or five weeks) and requires greater control by the optional.

In addition, its effect can be influenced by changes in the diet of the patient (certain foods that contain high amounts of vitamin K, as dark green leaf, some legumes like chickpeas, vegetables or chocolate can neutralize or enhance the effect), interaction with other medications or a mismatch in the dose, being able to produce a hemorrhage in the event of one higher dose or a significant reduction of the effects the drug, in the case of a lower consumption of the needy, with the consequent risk of stroke or clot formation.

“ For this reason that various studies to develop a drug to overcome the well-known problems of acenocoumarol, used in Spain, treatment with warfarin, used in the rest of the world are carrying out ”, emphasizes Dr. Julián Villacastín, Secretary general of the SEC. “ which seems more promising short-term treatment is the dabigatrancurrently marketed for the prevention of the formation of thrombi after orthopedic surgery for knee or hip and is expected to be approved as a treatment for atrial fibrillation by the end of this year ”, explains Dr. Pérez-Villacastín.

One of the studies that confirm the effectiveness of the dabigatran is RE-LY, made more than 18,000 patients and that, in comparison with warfarin and dose of 150 mg, reduces the risk of stroke or systemic embolism (1.69% prevalence in the studied patients who were given warfarin versus the 1.11% of the patients who took dabigatran), hemorrhagic stroke (0.35% warfarin vs. 0.10%), vascular mortality and total hemorrhages (3.36% with warfarin vs. 3.11% vs. dabigtran).

“ The study found the effectiveness of the dabigatran in dose of 150 mg and 110 mg to warfarin. The results showed that the dabigatran is the first oral anticoagulant that has proven to be better that warfarin, that at higher doses it turns out to be more effective, with similar bleeding rates, and lower doses, causes less bleeding than warfarin and is equally effective in preventing thromboembolic events ”, concludes Dr. Villacastín.

There are other studies showing the effectiveness of other blood-thinning treatments, it is the case of ARISTOTLE study 18,200 patients and which demonstrates that the apixaban compared with warfarin decreases the risk of stroke by 31% by 21% the risk of bleeding and death by 11%.

Study Rocket, for its part, the study Rocket has shown that it can compete with warfarin in preventing stroke, without significantly increasing the number of severe bleeding.

“ Studies of this type show the anticoagulant treatments currently used to have their days numbered, since emerging new treatments that result in less control by the optional, and greater comfort and quality of life for the patient ”, concludes Dr..

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Alicante celebrates the day of the nursing of Valencia under the motto nurses and chronicity. Binomial for the sustainability of the health system.

Alicante celebrates the day of the nursing of Valencia under the motto nurses and chronicity. Binomial for the sustainability of the health system.

chronic patients account for 80% of consultations in primary

alicante, October 2011.- El College of nursing of Alicante held last Friday 21, the day the nursing of Valencia under the banner of nurses and chronicity. Binomial for the sustainability of the health system, which is going to highlight the importance of the involvement and role of the profession nurse in care of patients with chronic diseases.

The day of the Valencian community nursing is a date established by the Council of the nursing of the Valencian Community (CECOVA) which joined the provincial schools of nursing regional organizing different events to enhance the profession and to society as a whole this celebration. With the election of a different motto each year is highlight one aspect of the profession nurse in order to make it visible.

With regard to the matter on which revolves the motto of this year should be noted that in Spain chronic diseases are the leading cause of health care demand in the health centres. Thus, the national survey of health in 2006 already evidenced an average of 2.8 problems or chronic diseases between 65 and 74 years of age, reaching an average of 3.23 in older than 75 years. Therefore, the ageing of the population and the increase in the prevalence of these diseases in recent years demand the need for a change in health systems.

Currently, chronic diseases are, as well as the main reason for death and disability worldwide, the leading cause of health expenditure in Spain, because in particular account for two-thirds of it, that costs in more than one chronic disease patients reach multiplied by six.

Assistance to patients with chronic diseases has become, at last, a political priority and nurses can and must play a key role in the improvement of health care. However, the potential of the synergies between health care administrations and collective health professionals not being realized, so it is essential to address thoroughly and throughout its whole planning of health care to chronicity, as a key aspect for the future sustainability of the public health system.

This type of pathology are going to have a very important role in the health system over the next years due to the increase in the life expectancy of the population, so to meet them with guarantees must count on a profession of nurse that is, to a greater extenthas the responsibility for direct care and care of such patients.

All health care systems are designed to care for chronically ill, and it cannot be otherwise because they are the largest group of patients with a difference. Thus, it is estimated that 78% of sanitary actions will target care of chronic diseases in the year 2020, which is why it is necessary to provide innovative solutions to ensure and improve access to health services.

Chronic patients currently registered figures represent 80% of consultations in primary care and almost 70 per cent of the emergency. Therefore the ultimate goal of administrations and of health professionals must be to improve the quality of life of the chronically ill, reduce unnecessary hospital admissions and preventable; slow the progression of the disease as far as possible, and promote self-care and participation active patients about their own illness.

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AstraZeneca and Forest Laboratories starts phase III of Ceftazidime/Avibactam clinical trials to treat serious infections caused by gram negative bacteria.

Astrazeneca and Forest Laboratories starts phase III of Ceftazidime/Avibactam clinical trials to treat serious infections caused by gram-negative bacteria.

Madrid, 2011-October, AstraZeneca and Forest Laboratories, Inc. have announced last Friday the start of clinical trials phase III with ceftazidime/avibactam (CAZ-AVI) to investigate its efficacy in the treatment of patients hospitalized with severe infections caused by gram-negative bacteria, including intra-abdominal infections complicated (IIAc) and infections complicated urinary tract (ITUc). CAZ-AVI combines a cephalosporin (ceftazidime) range with a novel inhibitor of beta-lactamases (avibactam, formerly NXL104) to overcome resistance to antibiotics and deal with the increasing number of infections resistant to current treatments.

This curriculum will include five trials phase III designed to demonstrate that CAZ-AVI is an effective and well tolerated treatment for patients with IIAc and ITUc including patients with infections that may be resistant to available antibiotics today.

This curriculum has been developed on the basis of the results of two individual phase II trials on CAZ-AVI:

-the trial phase II in IIAc showed that the effectiveness of CAZ-AVI administered metronidazole in adult patients was similar to meropenem, an established treatment given to patients with complicated intra-abdominal infections

-the trial phase II in Fusagasugá showed that the efficacy of CAZ-AVI in adult patients was similar to imipenem, cilastatinan established treatment given to patients with complicated urinary tract infections

-data from both trials showed that in general CAZ-AVI is tolerated well

“ this new step in the development of CAZ-AVI demonstrates our commitment to help meet the needs of hospitals who face additional health care costs linked to the rapid rise of antimicrobial-resistant microorganisms ”, said Anders Ekblom, Executive Vice President of Global Medicines Development (Global development of medicines) of AstraZeneca.

Dr. Marco Taglietti, Executive Vice President of research and development of Forest Laboratories and President of the Forest Research Institute, said: “ we are pleased to move forward with the agenda for development of CAZ-AVI. This combination of a broad-spectrum cephalosporin and a novel inhibitor of beta-lactamases has the potential to be effective against bacteria that otherwise would be resistant to antibiotics in patients with serious and life-threatening infections ”.

This curriculum is designed to endorse her international application of the marketing authorisation for scheduled for 2014.

As part of the collaboration, AstraZeneca and Forest will share the costs of the development of the treatment. Forest will take CAZ-AVI marketing rights in North America while AstraZeneca CAZ-AVI marketing rights in the rest of the world.

Phase III study program

development phase III scheduled program is designed to demonstrate that CAZ-AVI is an effective and well tolerated treatment for use in patients with infections caused by gram-negative, IIAc / or Fusagasugá, including those in which they are known or are suspected pathogens resistant to antibiotics normally used (such as the Enterobacteriaceae producing beta-lactamases of spectrum spread resistance to Penicillins and cephalosporins third grammar)(n).

studies phase II

complicated intra-abdominal infections (IIAc). This test phase II was a double blind, randomized study, prospective to estimate the efficacy, safety and tolerability of CAZ-AVI administered metronidazole to meropenem in the treatment of 203 adults hospitalized with IIAC requiring treatment with an intravenous antimicrobial. Patients treated with CAZ-AVI administered metronidazole had a high rate of clinical response (91.2% of patients) that was similar to that obtained in patients treated with meropenem (93.4% of patients)

complicated infections of the urinary tract (ITUc). This test phase II was a single-blind (for researchers), randomized, prospective to estimate the efficacy, safety and tolerability of CAZ-AVI to imipenem/cilastatin in the treatment of 135 adults hospitalized with Fusagasugá requiring treatment with an intravenous antimicrobial. Patients treated with CAZ-AVI had a high rate of complete eradication of pathogens (70.4% of patients) that was similar to that obtained in the patients treated with imipenem/cilastatin (71.4% of patients).

AstraZeneca collaboration/Forest in CAZ-AVI

In December 2009, AstraZeneca signed a contract to acquire Novexel, a private research of infections in France company at the same time announcing an agreement for collaboration with Forest Laboratories in the future co-development and commercialization of two antibiotics in late stage development programmes: ceftazidime/avibactam and ceftarolina fosamil/avibactam. These combinations of antibiotics used avibactam, novel experimental beta-lactamases of Novexel inhibitor, to overcome the resistance to antibiotics and deal with the increasing number of infections resistant to current treatments. AstraZeneca and Forest will share the costs of the development of CAZ-AVI.

About Forest Laboratories

International associations of Forest Laboratories (NYSE: FRX) and his career in the development and commercialization of pharmaceutical products in the United States, have culminated in its well-established franchises of cardiovascular and central nervous system and innovations in anti-infecciosa and respiratory medicine. The product portfolio in phase of development of the company, the more solid in its history, includes product candidates at all stages of development in a wide variety of therapeutic areas. The company is headquartered in New York, NY.

About AstraZeneca

AstraZeneca is an innovative company biopharmaceutical global focused mainly on the discovery, development and commercialization of prescription for the areas of gastrointestinal drugs, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious diseases. AstraZeneca operates in over 100 countries and their innovative medicines used by millions of patients around the world.

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Life extension, the organization dedicated to the anti aging more important in the world, reaches Spain.

Life extension, the organization dedicated to the anti-aging more important in the world, reaching Spain.

Has been working since 1980 in United States and level world.

– after more than 30 years leading research in United States and at the global level, Life extension has reached Spain in order to disseminate their findings and advanced formulas of last generation to fight ageing

-advances in weight control, innovations in anti-aging genetics, research on the Alzheimer’s disease, studies of regenerative medicine, hormone restoration or power generation and mitochondrial support, are some of the priority areas in which work the Life Extension Foundation

-Life extension products can be purchased online through the website of lifeextension

Madrid, 2011-October have a satisfactory and long life and a more healthy life expectancy is a goal that anyone would want to achieve. So the Life Extension Foundation, the largest medical organization non-profit dedicated to the long life of the world has been working since 1980. After more than 30 years leading research in United States and at the global level, Life extension has reached Spain in order to disseminate their findings and advanced formulas of last generation to fight ageing

Foundation is now working in various fields with the aim of discovering new methods and therapies to prevent diseases. Advances in weight control, innovations in anti-aging genetics, research on Alzheimer’s disease, studies of regenerative medicine, hormone restoration or power generation and mitochondrial support, are some of those priority areas for Life extension.

The results of Life extension over the past 30 years have made it possible to get a series of fundamental advances in medicine even before they were officially accepted:

1980-1989: antioxidants, polyphenols and Coenzyme Q10

in 1980 Life Extension was a pioneer in the recommendation to consume daily dose of antioxidants. Since then plenty of studies have backed this strategy. For example, Life Extension moved the rest when it began to isolate plant compounds called polyphenols, when nobody was talking about them.

In 1983, Life Extension made for the first time in the world, exactly in the US, than the Japanese drug Coenzyme Q10 is available as a nutritional supplement to powerful activity anti-aging. Today recognizes its potential to prevent and treat cardiovascular disease, Alzheimer’s, cancer …

1990-1999: the great growth of Life Extension

the 1990s was a time of great growth for the Foundation through the reception of the public who recognized the great progress that we have developed:

– in 1992, saw the light first melatonin in the world thanks to Life Extensionnowadays a widely recognized anti-aging substance.

– Life Extension published the theory of the poor as a cause of the aging DNA methylation in 1997. Today, many strategies focused on correct methylation are used against the depression, arteriosclerosis or liver problems.

– In 1998, Life Extension introduced in the United States a form of vitamin B12 called methylcobalamin that protects the brain from neurotoxins.

2000: Omega 3, vitamin D and Diabetes

Today everyone recognises the benefits of the consumption of Omega 3 fatty acids, but few are aware of the relevance of the studies published by Life Extension and thanks to his scientific funding in this recognition. In 2007, the Foundation published a study which confirmed that low values of Omega 3 EPA and DHA in blood were independent of angina and heart attack risk factors.

Recently, the Foundation reported that there are 366 million cases of diabetes in the world. In the last decade, has warned of a negative effect of high sugar levels: glycation. Today it is one of the most used theories of aging.

In 2009, Life Extension reitaraba its position on the importance of supplement levels higher in vitamin D, it offered to the US Government a massive donation of vitamin D supplements and began a study with almost 14,000 members of the Foundation to check the levels of vitamin D in them. Surprisingly, even among people who care for their diet and consume supplements, 85 ’ 7% had insufficient levels of vitamin D.

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Surah Al-Rehman – The Ultimate Free Remedy for Incurable Diseases

(By Listening Only- 20 Minutes Only)

Kindly download the Surah “AL-REHMAN” (recited by Qari Abdul Basit without translation) from here.


Treatment Plan

Just Listen to it three times a day (morning, afternoon, evening) for seven consecutive days using following procedure:-


    Before listening:

  • Close your eyes
  • Feel your self in front of ALLAH Almighty/ God
  • Then listen to it with greater concentration and closed eyes

    When the recitation/ AUDIO is finished:

  • Open your eyes and take half glass of water
  • Close your eyes again and say “ALLAH” three times in your heart with deep affection/ love
  • Then drink the water with closed eyes in three sips

Surah Al-Rehman – The Ultimate Free Remedy for Incurable Diseases

(By Listening Only- 20 Minutes Only)

Kindly download the Surah “AL-REHMAN” (recited by Qari Abdul Basit without translation) from here.


Treatment Plan

Just Listen to it three times a day (morning, afternoon, evening) for seven consecutive days using following procedure:-


    Before listening:

  • Close your eyes
  • Feel your self in front of ALLAH Almighty/ God
  • Then listen to it with greater concentration and closed eyes

    When the recitation/ AUDIO is finished:

  • Open your eyes and take half glass of water
  • Close your eyes again and say “ALLAH” three times in your heart with deep affection/ love
  • Then drink the water with closed eyes in three sips