new YORK (Reuters Health) – the newborn infants with
ischemic encephalopathy hypoxic ( EIH), whether it is severe or
moderate, to obtain better results if they are treated with
therapeutic hypothermia, shows a meta-analysis.
The discovery was kept even if the babies were handled
with cooling brain systemic or selective, said the
researchers.
“Doctors should be evaluated to provide therapeutic hypothermia
“
as part of these routine clinical care
“
born”, said the team of Canadian experts in an article
posted in Archives of Pediatrics and Adolescent Medicine.
El Dr. Mohamed a. Tagin, the Hospital for sick children
of Toronto, Ontario, and his colleagues claim that the
evidence to support hypothermia in the newborn infants with
EIH has been ambiguous. Recent reviews reported benefits
in the newborn infants with severe but not moderate encephalopathy
and vice-versa.
For this reason, experts conducted a systematic review
to assemble “all available information” and identified
seven and controlled trials randomised met all the
inclusion criteria.
Four trials used total body cooling and three,
selective head cooling compared to normothermia,
in a total of 1.214 newborn infants with moderate to severe EIH.
From the information collected, the proportion of
overall risk of death or major disability of the
neurodevelopment at 18 months was 0.76 with hipotermina,
compared to the normothermia, found the team. The
number-needed-try was 7 (seven).
In addition, hazard ratios were 0.75 with the
body cooling with selective cooling 0.77 and total
in the head, the report said. The benefit was extended to the
newborn infants with severe as those with EIH EIH
moderated.
Team also assessed the extent of risk of
disability and death separately.
“An important outcome of this review is that the
“
hypothermia reduced the mortality rate without increasing the rate of
“
disability in the asphyxiated infants”, indicated the
report. This was shown by a reduction in the rate of
important disability and an increase in the rate of
survival with normal neurological function.
. In conclusion, the doctor Tagin and colleagues commented that the
doctors should still be conservative in the advice of
parents on longer-term neurological function.
“Long-term follow-ups of the newborns in the
“
trials reported so far will provide data to examine
If the neurological information recorded 18 months predicts
“
a detailed neurological function in the long term”,
finished the authors.
The team added: “given that the result of suffocation to the
“
birth is devastadota, the work should continue to seek
“
adjuvant therapies to hypothermia”.
Source: Archives of Pediatrics and Adolescent Medicine,
online 6 February 2012
