They discover that the resveratrol protects against the neurotoxic effects of amyotrophic lateral sclerosis
MADRID, 26 (EUROPA PRESS) Researchers of the Autonomous University of Madrid have shown that resveratrol, a natural polyphenol with high-powered antioxidant found in various foods and plants, protects against the neurotoxic effects of sclerosis lateral amiotrófica (ELA), a serious degenerative disease that originates in motor neurons. The study, published in ' Brain Research ', has been developed by scientists of Institute Teófilo Hernando of the drug r & d, attached to the University. His research have also observed that the drug currently used in the therapy of this disease, the Riluzole, not only does not display Neuroprotective effects but may antagonize the beneficial effects of resveratrol. It has been postulated the existence of a toxic factor in cerebrospinal fluid (CSF) of patients of ELA as responsible for neuronal damage. However, studies are not yet clear in this regard, that the conclusions drawn are different depending on the number of samples tested, the neuronal lineage and the studied species. The researchers conducted various experiments to study the effect of CSF on cultivation of rat motor cortex neurons. As part of his study, incubated for 24 hours these neural crops with CSF from ALS patients and compared them with the effect caused by the CSF of healthy controls. In this way, noted that about 75 per cent of the CSF from ALS patients were significantly toxic to motor neurons of rat....
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