New YORK (Reuters Health) – the results of a
systematic review and a meta-analysis reinforced the idea of
that the inappropriate treatment plays an important role in the
rise of multi-drug-resistant tuberculosis
(MDR-TB).
The team of Dutch and Swedish researchers recognized
that is generally accepted that the inappropriate treatment
leads to an increase in the resistance, but experts
they wanted to obtain more evidence in this regard.
The study was published in European Respiratory Journal.
La Dr. Marieke j. van der Werf of the foundation of
KNCV tuberculosis in the Hague, and colleagues reviewed literature
and they found little information on treatment, regimens
drug prior to treatment resistance profiles
and before the failure or recurrence.
Diagnosis of MDR-TB required that patients
initially have the strain of Mycobacterium tuberculosis
susceptible at least to isoniazid or rifampicin to be
become MDR-TB at the time of treatment failure or
recurrence of the disease, and with a genotÃpico pattern
identical to the ECA initial.
The researchers finally identified and reviewed
four studies, ranging in size from 233 to 2.901
patients. Only two trials met the criteria for the
inclusion in the meta-analysis.
These two trials included over 3,200 patients and
they showed that the risk of developing MDR-TB is 27 times higher
in patients that is prescribed in a therapeutic regimen
inappropriate.
“Believe that there is little risk that patients who
“
is defined that they acquired MDR-TB in reality have been
“
re-infectado with an identical strain that was already MDR-TB”,
added the researchers.
“The new review provides evidence for the general opinion
“
of the development of MDR-TB may be due to the
“
(initial) treatment is inappropriate”, concluded the authors
who added: “the evidence is based on the studies
“”
available better quality”.
Source: European Respiratory Journal, 17 of October of the
2011
